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Whole Exome Sequencing-Global Market Insights and Sales Trends 2025
Synopsis
Exome sequencing is a capture based method developed to identify variants in the coding region of genes which affect protein function. While exome capture methods using PCR, hybrid capture and molecular inversion probes exist, the most common and efficient strategies are in-solution capture methods. In-solution capture utilizes pools of oligonucleotides or probes bound to magnetic beads, whose sequence has been designed to hybridize to exon regions. After binding to genomic DNA, these probes are pulled down and washed, allowing exon regions to be selectively sequenced.
While there are approximately 180,000 exons in the human genome, constituting less than 2% of total sequence, the exome contains ~80-90% of known disease causing variants making it a cost-effective alternative to whole genome sequencing. When performing exome-seq, users should not only consider average on-target coverage but also the local coverage of particular sites of interest. When choosing between exome and whole genome sequencing (WGS), consider that exome sequencing has the advantage that oligonucleotides are designed to particular genomic regions where typical coverage with WGS is not enough for SNP calling. It is also more affordable enabling the analysis of more individuals and populations. With WGS, you can detect variants in regions not covered by exome capture allowing or the identification of structural and non-coding variants associated with disease.
The global Whole Exome Sequencing market size is expected to reach US$ 635.7 million by 2029, growing at a CAGR of 11.4% from 2023 to 2029. The market is mainly driven by the significant applications of Whole Exome Sequencing in various end use industries. The expanding demands from the Correlation Research of Normal Human, Mendelian Disease and Rare Syndrome Gene Discovery, The Research of Complex Diseases and Mouse Exome Sequencing, are propelling Whole Exome Sequencing market. Agilent HaloPlex, one of the segments analysed in this report, is projected to record % CAGR and reach US$ million by the end of the analysis period. Growth in the Agilent SureSelect segment is estimated at % CAGR for the next seven-year period.
The major players in global Whole Exome Sequencing market include Illumina, Thermofisher, Roche, etc. The top 3 players occupy about 45% shares of the global market. North America and Europe are main markets, they occupy about 70% of the global market. Illumina TruSeq Exome and Roche Nimblegen SeqCap are main types, with a share about 55%. Mendelian Disease and Rare Syndrome Gene Discovery are the main application, which hold a share about 40%.
Report Objectives
This report provides market insight on the different segments, by players, by Type, by Application. Market size and forecast (2018-2029) has been provided in the report. The primary objectives of this report are to provide 1) global market size and forecasts, growth rates, market dynamics, industry structure and developments, market situation, trends; 2) global market share and ranking by company; 3) comprehensive presentation of the global market for Whole Exome Sequencing, with both quantitative and qualitative analysis through detailed segmentation; 4) detailed value chain analysis and review of growth factors essential for the existing market players and new entrants; 5) emerging opportunities in the market and the future impact of major drivers and restraints of the market.
Key Features of The Study:
This report provides in-depth analysis of the global Whole Exome Sequencing market, and provides market size (US$ million) and CAGR for the forecast period (2023-2029), considering 2022 as the base year.
This report profiles key players in the global Whole Exome Sequencing market based on the following parameters - company details (found date, headquarters, manufacturing bases), products portfolio, Whole Exome Sequencing sales data, market share and ranking.
This report elucidates potential market opportunities across different segments and explains attractive investment proposition matrices for this market.
This report illustrates key insights about market drivers, restraints, opportunities, market trends, regional outlook.
Key companies of Whole Exome Sequencing covered in this report include Illumina, Thermo Fisher, Roche, Angilent, Eurofins, Sengenics, Ambry, Macrogen and BGI, etc.
The global Whole Exome Sequencing market report caters to various stakeholders in this industry including investors, suppliers, product players, distributors, new entrants, and financial analysts.
Market Segmentation
Company Profiles:
Illumina
Thermo Fisher
Roche
Angilent
Eurofins
Sengenics
Ambry
Macrogen
BGI
Novo Gene
Global Whole Exome Sequencing market, by region:
North America (U.S., Canada, Mexico)
Europe (Germany, France, UK, Italy, etc.)
Asia Pacific (China, Japan, South Korea, Southeast Asia, India, etc.)
South America (Brazil, etc.)
Middle East and Africa (Turkey, GCC Countries, Africa, etc.)
Global Whole Exome Sequencing market, Segment by Type:
Agilent HaloPlex
Agilent SureSelect
Agilent SureSelect QXT
Illumina TruSeq Exome
Roche Nimblegen SeqCap
MYcroarray MYbaits
Global Whole Exome Sequencing market, by Application
Correlation Research of Normal Human
Mendelian Disease and Rare Syndrome Gene Discovery
The Research of Complex Diseases
Mouse Exome Sequencing
Core Chapters
Chapter One: Introduces the report scope of the report, executive summary of global and regional market size and CAGR for the history and forecast period (2018-2023, 2024-2029). It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter Two: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter Three: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter Four: Detailed analysis of Whole Exome Sequencing companies’ competitive landscape, revenue, market share and ranking, latest development plan, merger, and acquisition information, etc.
Chapter Five: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product introduction, revenue, recent development, etc.
Chapter Six, Seven, Eight, Nine and Ten: North America, Europe, Asia Pacific, Latin America, Middle East & Africa, revenue by country.
Chapter Eleven: this section also introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by companies in the industry, and the analysis of relevant policies in the industry.
Chapter Twelve: Research Finding/Conclusion
Exome sequencing is a capture based method developed to identify variants in the coding region of genes which affect protein function. While exome capture methods using PCR, hybrid capture and molecular inversion probes exist, the most common and efficient strategies are in-solution capture methods. In-solution capture utilizes pools of oligonucleotides or probes bound to magnetic beads, whose sequence has been designed to hybridize to exon regions. After binding to genomic DNA, these probes are pulled down and washed, allowing exon regions to be selectively sequenced.
While there are approximately 180,000 exons in the human genome, constituting less than 2% of total sequence, the exome contains ~80-90% of known disease causing variants making it a cost-effective alternative to whole genome sequencing. When performing exome-seq, users should not only consider average on-target coverage but also the local coverage of particular sites of interest. When choosing between exome and whole genome sequencing (WGS), consider that exome sequencing has the advantage that oligonucleotides are designed to particular genomic regions where typical coverage with WGS is not enough for SNP calling. It is also more affordable enabling the analysis of more individuals and populations. With WGS, you can detect variants in regions not covered by exome capture allowing or the identification of structural and non-coding variants associated with disease.
The global Whole Exome Sequencing market size is expected to reach US$ 635.7 million by 2029, growing at a CAGR of 11.4% from 2023 to 2029. The market is mainly driven by the significant applications of Whole Exome Sequencing in various end use industries. The expanding demands from the Correlation Research of Normal Human, Mendelian Disease and Rare Syndrome Gene Discovery, The Research of Complex Diseases and Mouse Exome Sequencing, are propelling Whole Exome Sequencing market. Agilent HaloPlex, one of the segments analysed in this report, is projected to record % CAGR and reach US$ million by the end of the analysis period. Growth in the Agilent SureSelect segment is estimated at % CAGR for the next seven-year period.
The major players in global Whole Exome Sequencing market include Illumina, Thermofisher, Roche, etc. The top 3 players occupy about 45% shares of the global market. North America and Europe are main markets, they occupy about 70% of the global market. Illumina TruSeq Exome and Roche Nimblegen SeqCap are main types, with a share about 55%. Mendelian Disease and Rare Syndrome Gene Discovery are the main application, which hold a share about 40%.
Report Objectives
This report provides market insight on the different segments, by players, by Type, by Application. Market size and forecast (2018-2029) has been provided in the report. The primary objectives of this report are to provide 1) global market size and forecasts, growth rates, market dynamics, industry structure and developments, market situation, trends; 2) global market share and ranking by company; 3) comprehensive presentation of the global market for Whole Exome Sequencing, with both quantitative and qualitative analysis through detailed segmentation; 4) detailed value chain analysis and review of growth factors essential for the existing market players and new entrants; 5) emerging opportunities in the market and the future impact of major drivers and restraints of the market.
Key Features of The Study:
This report provides in-depth analysis of the global Whole Exome Sequencing market, and provides market size (US$ million) and CAGR for the forecast period (2023-2029), considering 2022 as the base year.
This report profiles key players in the global Whole Exome Sequencing market based on the following parameters - company details (found date, headquarters, manufacturing bases), products portfolio, Whole Exome Sequencing sales data, market share and ranking.
This report elucidates potential market opportunities across different segments and explains attractive investment proposition matrices for this market.
This report illustrates key insights about market drivers, restraints, opportunities, market trends, regional outlook.
Key companies of Whole Exome Sequencing covered in this report include Illumina, Thermo Fisher, Roche, Angilent, Eurofins, Sengenics, Ambry, Macrogen and BGI, etc.
The global Whole Exome Sequencing market report caters to various stakeholders in this industry including investors, suppliers, product players, distributors, new entrants, and financial analysts.
Market Segmentation
Company Profiles:
Illumina
Thermo Fisher
Roche
Angilent
Eurofins
Sengenics
Ambry
Macrogen
BGI
Novo Gene
Global Whole Exome Sequencing market, by region:
North America (U.S., Canada, Mexico)
Europe (Germany, France, UK, Italy, etc.)
Asia Pacific (China, Japan, South Korea, Southeast Asia, India, etc.)
South America (Brazil, etc.)
Middle East and Africa (Turkey, GCC Countries, Africa, etc.)
Global Whole Exome Sequencing market, Segment by Type:
Agilent HaloPlex
Agilent SureSelect
Agilent SureSelect QXT
Illumina TruSeq Exome
Roche Nimblegen SeqCap
MYcroarray MYbaits
Global Whole Exome Sequencing market, by Application
Correlation Research of Normal Human
Mendelian Disease and Rare Syndrome Gene Discovery
The Research of Complex Diseases
Mouse Exome Sequencing
Core Chapters
Chapter One: Introduces the report scope of the report, executive summary of global and regional market size and CAGR for the history and forecast period (2018-2023, 2024-2029). It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter Two: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter Three: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter Four: Detailed analysis of Whole Exome Sequencing companies’ competitive landscape, revenue, market share and ranking, latest development plan, merger, and acquisition information, etc.
Chapter Five: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product introduction, revenue, recent development, etc.
Chapter Six, Seven, Eight, Nine and Ten: North America, Europe, Asia Pacific, Latin America, Middle East & Africa, revenue by country.
Chapter Eleven: this section also introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by companies in the industry, and the analysis of relevant policies in the industry.
Chapter Twelve: Research Finding/Conclusion
Index1 Market Overview of Whole Exome Sequencing
1.1 Whole Exome Sequencing Market Overview
1.1.1 Whole Exome Sequencing Product Scope
1.1.2 Whole Exome Sequencing Market Status and Outlook
1.2 Global Whole Exome Sequencing Market Size Overview by Region 2018 VS 2022 VS 2029
1.3 Global Whole Exome Sequencing Market Size by Region (2018-2029)
1.4 Global Whole Exome Sequencing Historic Market Size by Region (2018-2023)
1.5 Global Whole Exome Sequencing Market Size Forecast by Region (2024-2029)
1.6 Key Regions, Whole Exome Sequencing Market Size (2018-2029)
1.6.1 North America Whole Exome Sequencing Market Size (2018-2029)
1.6.2 Europe Whole Exome Sequencing Market Size (2018-2029)
1.6.3 Asia-Pacific Whole Exome Sequencing Market Size (2018-2029)
1.6.4 Latin America Whole Exome Sequencing Market Size (2018-2029)
1.6.5 Middle East & Africa Whole Exome Sequencing Market Size (2018-2029)
2 Whole Exome Sequencing Market by Type
2.1 Introduction
2.1.1 Agilent HaloPlex
2.1.2 Agilent SureSelect
2.1.3 Agilent SureSelect QXT
2.1.4 Illumina TruSeq Exome
2.1.5 Roche Nimblegen SeqCap
2.1.6 MYcroarray MYbaits
2.2 Global Whole Exome Sequencing Market Size by Type: 2018 VS 2022 VS 2029
2.2.1 Global Whole Exome Sequencing Historic Market Size by Type (2018-2023)
2.2.2 Global Whole Exome Sequencing Forecasted Market Size by Type (2024-2029)
2.3 Key Regions Market Size by Type
2.3.1 North America Whole Exome Sequencing Revenue Breakdown by Type (2018-2029)
2.3.2 Europe Whole Exome Sequencing Revenue Breakdown by Type (2018-2029)
2.3.3 Asia-Pacific Whole Exome Sequencing Revenue Breakdown by Type (2018-2029)
2.3.4 Latin America Whole Exome Sequencing Revenue Breakdown by Type (2018-2029)
2.3.5 Middle East and Africa Whole Exome Sequencing Revenue Breakdown by Type (2018-2029)
3 Whole Exome Sequencing Market Overview by Application
3.1 Introduction
3.1.1 Correlation Research of Normal Human
3.1.2 Mendelian Disease and Rare Syndrome Gene Discovery
3.1.3 The Research of Complex Diseases
3.1.4 Mouse Exome Sequencing
3.2 Global Whole Exome Sequencing Market Size by Application: 2018 VS 2022 VS 2029
3.2.1 Global Whole Exome Sequencing Historic Market Size by Application (2018-2023)
3.2.2 Global Whole Exome Sequencing Forecasted Market Size by Application (2024-2029)
3.3 Key Regions Market Size by Application
3.3.1 North America Whole Exome Sequencing Revenue Breakdown by Application (2018-2029)
3.3.2 Europe Whole Exome Sequencing Revenue Breakdown by Application (2018-2029)
3.3.3 Asia-Pacific Whole Exome Sequencing Revenue Breakdown by Application (2018-2029)
3.3.4 Latin America Whole Exome Sequencing Revenue Breakdown by Application (2018-2029)
3.3.5 Middle East and Africa Whole Exome Sequencing Revenue Breakdown by Application (2018-2029)
4 Whole Exome Sequencing Competition Analysis by Players
4.1 Global Whole Exome Sequencing Market Size by Players (2018-2023)
4.2 Global Top Players by Company Type (Tier 1, Tier 2 and Tier 3) & (based on the Revenue in Whole Exome Sequencing as of 2022)
4.3 Date of Key Players Enter into Whole Exome Sequencing Market
4.4 Global Top Players Whole Exome Sequencing Headquarters and Area Served
4.5 Key Players Whole Exome Sequencing Product Solution and Service
4.6 Competitive Status
4.6.1 Whole Exome Sequencing Market Concentration Rate
4.6.2 Mergers & Acquisitions, Expansion Plans
5 Company (Top Players) Profiles
5.1 Illumina
5.1.1 Illumina Profile
5.1.2 Illumina Main Business
5.1.3 Illumina Whole Exome Sequencing Products, Services and Solutions
5.1.4 Illumina Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.1.5 Illumina Recent Developments
5.2 Thermo Fisher
5.2.1 Thermo Fisher Profile
5.2.2 Thermo Fisher Main Business
5.2.3 Thermo Fisher Whole Exome Sequencing Products, Services and Solutions
5.2.4 Thermo Fisher Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.2.5 Thermo Fisher Recent Developments
5.3 Roche
5.3.1 Roche Profile
5.3.2 Roche Main Business
5.3.3 Roche Whole Exome Sequencing Products, Services and Solutions
5.3.4 Roche Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.3.5 Angilent Recent Developments
5.4 Angilent
5.4.1 Angilent Profile
5.4.2 Angilent Main Business
5.4.3 Angilent Whole Exome Sequencing Products, Services and Solutions
5.4.4 Angilent Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.4.5 Angilent Recent Developments
5.5 Eurofins
5.5.1 Eurofins Profile
5.5.2 Eurofins Main Business
5.5.3 Eurofins Whole Exome Sequencing Products, Services and Solutions
5.5.4 Eurofins Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.5.5 Eurofins Recent Developments
5.6 Sengenics
5.6.1 Sengenics Profile
5.6.2 Sengenics Main Business
5.6.3 Sengenics Whole Exome Sequencing Products, Services and Solutions
5.6.4 Sengenics Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.6.5 Sengenics Recent Developments
5.7 Ambry
5.7.1 Ambry Profile
5.7.2 Ambry Main Business
5.7.3 Ambry Whole Exome Sequencing Products, Services and Solutions
5.7.4 Ambry Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.7.5 Ambry Recent Developments
5.8 Macrogen
5.8.1 Macrogen Profile
5.8.2 Macrogen Main Business
5.8.3 Macrogen Whole Exome Sequencing Products, Services and Solutions
5.8.4 Macrogen Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.8.5 Macrogen Recent Developments
5.9 BGI
5.9.1 BGI Profile
5.9.2 BGI Main Business
5.9.3 BGI Whole Exome Sequencing Products, Services and Solutions
5.9.4 BGI Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.9.5 BGI Recent Developments
5.10 Novo Gene
5.10.1 Novo Gene Profile
5.10.2 Novo Gene Main Business
5.10.3 Novo Gene Whole Exome Sequencing Products, Services and Solutions
5.10.4 Novo Gene Whole Exome Sequencing Revenue (US$ Million) & (2018-2023)
5.10.5 Novo Gene Recent Developments
6 North America
6.1 North America Whole Exome Sequencing Market Size by Country (2018-2029)
6.2 U.S.
6.3 Canada
7 Europe
7.1 Europe Whole Exome Sequencing Market Size by Country (2018-2029)
7.2 Germany
7.3 France
7.4 U.K.
7.5 Italy
7.6 Russia
7.7 Nordic Countries
7.8 Rest of Europe
8 Asia-Pacific
8.1 Asia-Pacific Whole Exome Sequencing Market Size by Region (2018-2029)
8.2 China
8.3 Japan
8.4 South Korea
8.5 Southeast Asia
8.6 India
8.7 Australia
8.8 Rest of Asia-Pacific
9 Latin America
9.1 Latin America Whole Exome Sequencing Market Size by Country (2018-2029)
9.2 Mexico
9.3 Brazil
9.4 Rest of Latin America
10 Middle East & Africa
10.1 Middle East & Africa Whole Exome Sequencing Market Size by Country (2018-2029)
10.2 Turkey
10.3 Saudi Arabia
10.4 UAE
10.5 Rest of Middle East & Africa
11 Whole Exome Sequencing Market Dynamics
11.1 Whole Exome Sequencing Industry Trends
11.2 Whole Exome Sequencing Market Drivers
11.3 Whole Exome Sequencing Market Challenges
11.4 Whole Exome Sequencing Market Restraints
12 Research Finding /Conclusion
13 Methodology and Data Source
13.1 Methodology/Research Approach
13.1.1 Research Programs/Design
13.1.2 Market Size Estimation
13.1.3 Market Breakdown and Data Triangulation
13.2 Data Source
13.2.1 Secondary Sources
13.2.2 Primary Sources
13.3 Disclaimer
13.4 Author List
Published By : QY Research
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